8 ohdg antibody (MedChemExpress)
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8 ohdg antibody
8 Ohdg Antibody, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/8+ohdg/8-OHdG+(DNA%2FRNA+Damage)+Antibody/pmc13157191-14-0-3
Average 94 stars, based on 1 article reviews
8 Ohdg Antibody, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/8+ohdg/8-OHdG+(DNA%2FRNA+Damage)+Antibody/pmc13157191-14-0-3
Average 94 stars, based on 1 article reviews
8 ohdg antibody - by Bioz Stars,
2026-10
94/100 stars
Images
1) Product Images from "Aluminum exposure impairs nuclear envelope breakdown for mouse zygote formation"
Article Title: Aluminum exposure impairs nuclear envelope breakdown for mouse zygote formation
Journal: iScience
doi: 10.1016/j.isci.2026.115807
Figure Legend Snippet: Aluminum exposure triggers mitochondrial dysfunction, oxidative damage accumulation and apoptosis in mouse zygotes (A) Representative images of mitochondrial distribution in zygotes of the control and treatment groups by immunofluorescence staining. Red, mitochondria; blue, DNA. Scale bars, 20 μm. (B) Relative fluorescence intensity and abnormal rate of mitochondria. The relative fluorescence intensity: control, n = 47; AlCl 3 , n = 50; ∗∗ p < 0.005; abnormal rate: control, n = 47; AlCl 3 , n = 50; ∗∗∗ p < 0.0005. (C) TMRE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, TMRE; blue, DNA. Scale bars, 20 μm. (D) Relative fluorescence intensity of TMRE. Control, n = 45; AlCl 3 , n = 46; ∗ p < 0.05. (E) ROS-positive rate in zygotes of the control and treatment groups at 5.5 h, 6 h, 9 h, and 12 h post-fertilization by immunofluorescence staining. Green, ROS. Scale bars, 80 μm. (5.5 h corresponds to 30 min after AlCl 3 treatment, 6 h to 1 h, 9 h–4 h, and 12 h–7 h after AlCl 3 treatment). (F) ROS-positive rate in zygotes at different time points post-fertilization. 5.5 h: control, n = 39; AlCl 3 , n = 38; ∗∗∗ p < 0.0005; 6 h: control, n = 45; AlCl 3 , n = 47; ∗∗ p < 0.005; 9 h: control, n = 41; AlCl 3 , n = 42; ∗ p < 0.05; 12 h: control, n = 38; AlCl 3 , n = 46; ∗∗∗∗ p < 0.0001. (G) The mRNA expression level of Cox1 . ∗∗∗ p < 0.0005. (H) 8-OHdG levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 8-OHdG; blue, DNA. Scale bars, 20 μm. (I) Relative fluorescence intensity of 8-OHdG. Control, n = 41; AlCl 3 , n = 39; ∗∗ p < 0.005. (J) The 4-HNE levels in zygotes of the control and treatment groups by immunofluorescence staining. Red, 4-HNE; blue, DNA. Scale bars, 20 μm. (K) Relative fluorescence intensity of 4-HNE. Control, n = 39; AlCl 3 , n = 41; ∗∗∗∗ p < 0.0001. (L) The mRNA expression levels of oxidative stress-related genes. ∗∗ p < 0.005, ∗∗ p < 0.01, ∗ p < 0.05, ∗∗∗ p < 0.0005. (M) Representative images of early apoptosis in control and AlCl 3 -exposed groups by immunofluorescence staining. Green, annexin-V. Scale bars, 20 μm. (N) Apoptosis rate of zygotes. Control, n = 56; AlCl 3 , n = 50; ∗∗ p < 0.005. (O) The mRNA expression levels of apoptosis-related genes. ∗∗ p < 0.01, ∗∗ p < 0.005, ∗ p < 0.05. Data are presented as mean ± SEM. All experiments were performed in three independent biological replicates, with three technical replicates per biological replicate; mouse zygotes were used as research subjects. n represents the number of zygotes analyzed. Statistical analysis was performed using paired t tests. Asterisks indicate statistical significance: ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
Techniques Used: Control, Immunofluorescence, Staining, Fluorescence, Expressing
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